Mechanistic Evaluation of Therapeutic Targets derived from Treatable Traits to Improve CNS Outcomes in People with HIV (R21/R33 Clinical Trial Not Allowed)

This grant funds research to identify modifiable mechanisms and therapeutic targets for HIV-associated central nervous system complications. It supports a phased approach that first defines patient phenotypes with shared pathophysiology, then discovers and experimentally validates molecular mechanisms using innovative in-vitro and in-vivo models.