Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD) (UG3/UH3 Clinical Trial Required)
This grant invites bundled phase 1 and phase 1b/2a trials to streamline early-stage evaluation of novel pharmacological agents for Alzheimer’s disease and related dementias. It funds small-molecule or biologic interventions that target non-amyloid/non-tau mechanisms and aim to improve cognitive or neuropsychiatric symptoms across disease stages, with required safety and tolerability go/no-go milestones.
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