Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
This grant supports investigator-initiated single-site clinical trials, including efficacy, comparative effectiveness, pragmatic, and dissemination/implementation science studies, and encourages innovative designs such as platform, adaptive, and Bayesian trials. It funds trials testing therapeutic, behavioral, or prevention strategies that align with the NHLBI research mission, requiring a detailed scientific and operational plan.
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