Systematic Characterization of Genomic Variation to Assess Effects of Individual Variants on Genome Function and Phenotype (UM1 Clinical Trials Not Allowed)
This grant funds centers that systematically perturb genomic variants using high-throughput methods, collect data on their effects on DNA, RNA, or protein-coding elements, and develop robust, reproducible data pipelines. The funded centers will join the Impact of Genomic Variation on Function Consortium and collaborate on assays, variants, cell types, and shared analysis strategies.
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